Inhaled glucocorticoids promotes osteoporosis in asthma patients

نویسندگان

  • Mojtaba Eizadi 1. Department of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran.
چکیده مقاله:

Background: Recently many studies have focused on the possible role of corticosteroids inhalation on osteoporosis in asthma patients. This study aimed to determine whether the indicatives of bone formation or resorption are different between asthma patients with healthy subjects. Materials and Methods: To achieve this outcome, twenty one middle-aged asthma patients treated with inhaled corticosteroid and the same number healthy individuals matched for age (38 ± 6.5 years of old) participated in this study by accessible sampling. All subjects were non-trained and no smoker. Serum osteocalcin (OC), alkaline phosphatase (ALP) and cross-linked telopeptides of type I collagen (CTX) were measured to assess and compare bone formation and resorption between 2 groups. An Independent sample T-test was used to compare all variables between asthma and healthy subjects. Results: Significant differences were not observed in body weight and other anthropometrical markers between 2 groups (p > 0.05). Serum osteocalcin have shown a borderline significant lower in asthma patients than healthy subjects (p = 0.051). ALP was significantly lower in asthma patients than healthy subjects (p = 0.021). But serum CTX levels were higher in asthma patients than in healthy subjects (p=0.014). Conclusion: Based on these finding, it is appear that inhaled corticosteroid in asthma patients can be affect bone turnover in asthma patients, although more research is needed to further explore any potential link between corticosteroids and osteoporosis.  

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Escalating Inhaled Glucocorticoids to Prevent Asthma Exacerbations.

Inhaled glucocorticoids are pivotal to achieve asthma control and disease stability in both children and adults; despite their use, with or without other treatments, many patients with asthma have ongoing episodic disease exacerbations.1 Often, these are linked to provocative factors such as viral or bacterial infections, nonadherence to treatment, allergen exposure, and environmental air pollu...

متن کامل

Five year study of etidronate and/or calcium as prevention and treatment for osteoporosis and fractures in patients with asthma receiving long term oral and/or inhaled glucocorticoids.

BACKGROUND Glucocorticoids are associated with a reduction in bone density and an increased risk of fracture. Concurrent treatment with bisphosphonates reduces bone loss and may prevent fractures. A randomised study was performed to determine whether treatment with cyclical etidronate and/or calcium for 5 years prevents fractures or reverses/reduces bone loss in patients receiving glucocorticoi...

متن کامل

Asthma and Therapeutics: Inhaled Corticosteroids, Corticosteroid Osteoporosis, and the Risk of Fracture in Chronic Asthma

Current guidelines for the diagnosis and treatment of osteoporosis do not address the risks to bone density and the likelihood of fracture that may be associated with inhaled corticosteroid treatment for asthma. This review outlines an approach to the use of bone densitometry in clinical practice for the diagnosis, prevention, and treatment of osteoporosis in asthmatic patients receiving inhale...

متن کامل

Inhaled glucocorticoids and COPD exacerbations.

n engl j med 372;1 nejm.org january 1, 2015 92 for transfusion in our clinical setting.3 The benefit of using the lactate level and Scvo2 to initiate and guide early resuscitation, including transfusion, in patients with septic shock may be questioned after the results of recent randomized trials.4,5 As compared with the high-quality data from these trials, the results of any post hoc subgroup ...

متن کامل

Transcriptional potencies of inhaled glucocorticoids.

Glucocorticoids (GC) are the most effective anti-inflammatory drugs used in asthma. By a process called trans-activation, they increase the transcription of genes involved in either beneficial processes or certain side effects. Through trans-repression, they inhibit the transcription factors nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1), thereby decreasing the expression of ...

متن کامل

Inhaled corticosteroids can reduce osteoporosis in female patients with COPD

BACKGROUND Whether the use of inhaled corticosteroids (ICSs) in patients with COPD can protect from osteoporosis remains undetermined. The aim of this study is to assess the incidence of osteoporosis in patients with COPD with ICS use and without. PATIENTS AND METHODS This is a retrospective cohort and population-based study in which we extracted newly diagnosed female patients with COPD betw...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 5  شماره 4

صفحات  0- 0

تاریخ انتشار 2017-11

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023